1612-哺乳动物双重内分泌腺的甲状腺谱系演变 episode artwork

EPISODE · Sep 25, 2026 · 21 MIN

1612-哺乳动物双重内分泌腺的甲状腺谱系演变

from 聊聊Sci

这篇文章探讨了哺乳动物甲状腺作为双重内分泌器官的胚胎发育机制。研究人员通过单细胞转录组学技术,揭示了产生甲状腺激素的滤泡细胞与产生降钙素的C细胞各自不同的发育轨迹及其关键转录因子。研究发现,起源于第四咽囊的后鳃体在与甲状腺原基融合的过程中,经历了显著的细胞外基质重塑和基底膜降解,使C细胞得以整合进甲状腺。此外,这种胚胎期的上皮-间质演变在甲状腺癌的侵袭过程中会被重新激活,为理解肿瘤演化提供了新视角。该研究通过构建基因调节网络,系统地阐明了维持甲状腺双重功能的分子基础。References:Lobo M, Johansson E, Kumari S, et al. Resolving thyroid lineage cell trajectories merging into a dual endocrine gland in mammals[J]. Nature Communications, 2026.前往小宇宙评论区与主播互动

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1612-哺乳动物双重内分泌腺的甲状腺谱系演变

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