EPISODE · Sep 25, 2026 · 23 MIN
1613-乳腺癌组织流态化中的力学代谢反馈与免疫激活
from 聊聊Sci
这些研究探讨了乳腺癌中组织流动性与先天免疫之间的机械代谢反馈机制。研究发现，RAB5A蛋白诱导的组织流体化会引发机械应力，通过AMPK–AKAP1–DRP1通路导致线粒体过度融合并产生损伤。这种亚致死性的损伤促使线粒体DNA（mtDNA）释放到细胞质中，进而激活cGAS–STING免疫信号通路。研究进一步揭示了GASDERMIN A在放大这一炎症反馈环路中的关键作用，使肿瘤从“冷”转“热”。最终，这种机制增强了免疫系统对肿瘤的监测能力，并显著提升了乳腺癌对免疫检查点阻断疗法的敏感性。References:Palamidessi A, Frittoli E, Corada M, et al. Mechano-metabolic feedback connects tissue fluidity to mitochondrial DNA–dependent immunity in breast cancer[J]. Nature Communications, 2026.前往小宇宙评论区与主播互动
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