EPISODE · Sep 26, 2026 · 21 MIN
1617-Nur77激动剂增强自然杀伤细胞抗肝癌免疫力
from 聊聊Sci
本文揭示了核受体Nur77在增强自然杀伤（NK）细胞抗肝癌免疫力中的核心作用。研究团队通过空间转录组学和单细胞测序发现，Nur77的表达与肝癌患者更好的生存预后密切相关，并能驱动NK细胞的活化与增殖。实验证明，缺失该蛋白会导致NK细胞功能受损并加速肿瘤生长，而使用小分子激动剂Cytosporone B激活Nur77则能显著增强其杀伤效力。从机制上看，Nur77通过抑制CD36的表达，帮助NK细胞抵御肿瘤微环境中的脂质代谢抑制。此外，预处理后的NK细胞在过继性细胞疗法中表现出更强的肿瘤浸润能力和治疗效果。该研究为开发针对实体瘤的高效免疫治疗方案提供了重要的新靶点。References:Neo S Y, Mei Y, Chong J, et al. Nur77 agonism invigorates Natural Killer cell immunity against hepatocellular carcinoma[J]. Nature Communications, 2026.前往小宇宙评论区与主播互动
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1617-Nur77激动剂增强自然杀伤细胞抗肝癌免疫力
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