EPISODE · Sep 26, 2026 · 20 MIN
1619-星形胶质细胞层粘连蛋白驱动脑转移癌细胞休眠
from 聊聊Sci
这项研究通过活体成像和高维度分析，揭示了三阴性乳腺癌向脑部转移的关键机制，指出逃离休眠状态而非进入脑部是疾病进展的瓶颈。研究发现，分布在血管周围的播散性肿瘤细胞（DTCs）通过其表面的营养不良糖蛋白（dystroglycan）受体接收来自星形胶质细胞生成的层粘连蛋白-211的信号。这种信号轴将促生长转录因子YAP锁定在细胞质内，从而维持肿瘤细胞的休眠状态。然而，当血管周围的星形胶质细胞足突脱落导致层粘连蛋白流失时，YAP会转移至细胞核并激活生长程序，最终诱发脑转移。这一发现确立了脑部微环境特有的抑癌机制，并为开发维持肿瘤休眠或预防脑转移的新疗法奠定了理论基础。References:Dai J, Cimino P J, Gouin III K H, et al. Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain[J]. Nature Cancer, 2022, 3(1): 25-42.前往小宇宙评论区与主播互动
Embed this episode
Ready to play
1619-星形胶质细胞层粘连蛋白驱动脑转移癌细胞休眠
0:00
20:38
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Forfeiture Book Review: Ecocide and Sci-Fi
JP et al.
A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra
Deep Dream State
Neural Nets And Pretty Patterns
Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 20 minutes long.
When was this 聊聊Sci episode published?
This episode was published on September 26, 2026.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!