EPISODE · Sep 28, 2026 · 17 MIN
1625-大型真核DNA病毒编码ESCRT膜重塑系统
from 聊聊Sci
这篇研究披露了在米鲁病毒（mirusviruses）及部分核质病毒（Nucleocytoviricota）中首次发现了病毒编码的ESCRT复合体组分。这类被称为vESCRT的蛋白质包含核心的ESCRT-III类似物和Vps4 ATP酶，具有介导细胞膜重塑和断裂的功能。研究指出，病毒可能在演化早期从宿主细胞中“劫持”了这些基因，以实现更具自主性的病毒包膜形成与出芽过程。通过系统发育分析与结构预测，科学家揭示了这些病毒组分与真核生物及阿斯加德古菌同源蛋白之间的紧密联系。这一发现不仅改写了病毒利用宿主机器的传统认知，还暗示了大型DNA病毒在膜动力学控制方面拥有此前未知的自主权。References:Medvedeva S, Guyet U, Koonin E V, et al. Large eukaryotic DNA viruses encode ESCRT machinery for membrane remodelling[J]. Nature Microbiology, 2026: 1-6.前往小宇宙评论区与主播互动
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1625-大型真核DNA病毒编码ESCRT膜重塑系统
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