EPISODE · Sep 29, 2026 · 21 MIN
1629-大肠杆菌入侵前列腺管腔细胞的分子机制研究
from 聊聊Sci
这项研究利用小鼠干细胞开发了一种创新的二维前列腺上皮类器官模型，旨在探究泌尿致病性大肠杆菌（UPEC）引发前列腺炎的分子机制。研究发现，这种细菌会特异性地侵入并寄生在管腔前列腺细胞中，这一过程依赖于细菌的FimH粘附素与宿主细胞表面特有的前列腺酸性磷酸酶（PPAP）受体之间的结合。实验证明，D-甘露糖能有效阻断这种相互作用，从而抑制细菌的感染与增殖。通过对人类前列腺组织的离体实验和基因敲除模型的验证，该研究确立了PPAP作为UPEC感染关键受体的地位。这些成果不仅揭示了前列腺炎的致病通路，还为开发针对FimH受体的新型临床治疗方案提供了重要依据。References:Guedes M, Peters S, Joshi A, et al. Uropathogenic Escherichia coli invade luminal prostate cells via FimH–PPAP receptor binding[J]. Nature Microbiology, 2026, 11(2): 535-550.前往小宇宙评论区与主播互动
Embed this episode
Ready to play
1629-大肠杆菌入侵前列腺管腔细胞的分子机制研究
0:00
21:08
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Forfeiture Book Review: Ecocide and Sci-Fi
JP et al.
A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra
Deep Dream State
Neural Nets And Pretty Patterns
Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 21 minutes long.
When was this 聊聊Sci episode published?
This episode was published on September 29, 2026.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!