EPISODE · Sep 30, 2026 · 20 MIN
1631-晚期肾癌治疗耐药的单细胞图谱与免疫逃逸机制研究
from 聊聊Sci
这项研究通过单细胞转录组测序分析，揭示了晚期肾细胞癌在接受酪氨酸激酶抑制剂（TKI）与免疫检查点抑制剂（ICI）联合治疗时的耐药机制。研究人员发现，SAA+肿瘤细胞会诱导具有免疫抑制特性的CEACAM1+中性粒细胞浸润，进而导致CD8+ T细胞功能竭制。通过建立单细胞图谱，该研究确立了由SAA–CEACAM1–TIM-3构成的免疫抑制轴是驱动治疗失效的关键因素。在动物实验中，阻断该信号轴能显著逆转耐药性并增强抗肿瘤疗效。这些发现不仅为临床预后提供了SAA这一潜在的生物标志物，也为攻克肾癌耐药性指明了新的精准治疗靶点。References:Gu L, Zhang Q, Liang Q, et al. PD-1 blockade plus tyrosine kinase inhibitor remodels the tumor microenvironment in advanced renal cell carcinoma[J]. Nature Communications, 2026, 17(1): 4626.前往小宇宙评论区与主播互动
Embed this episode
Ready to play
1631-晚期肾癌治疗耐药的单细胞图谱与免疫逃逸机制研究
0:00
20:25
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Forfeiture Book Review: Ecocide and Sci-Fi
JP et al.
A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra
Deep Dream State
Neural Nets And Pretty Patterns
Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 20 minutes long.
When was this 聊聊Sci episode published?
This episode was published on September 30, 2026.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!