EPISODE · Oct 2, 2026 · 27 MIN
1636-外周血肿瘤反应性T细胞表型预测肺癌免疫疗效
from 聊聊Sci
这份研究探讨了通过外周血中的循环肿瘤反应性T细胞（cTR-T）来预测非小细胞肺癌患者对免疫检查点抑制剂治疗反应的方法。研究人员利用单细胞测序技术识别出了cTR-T特有的表面标志物，如CD49a、CD49b和HLA-DR，并发现这些细胞具有祖细胞样表型，能够向肿瘤内部迁移。实验表明，治疗前cTR-T中CD38的低表达以及治疗后细胞向干细胞样表型的转变，与良好的临床疗效密切相关。通过小鼠模型验证，该研究证明了cTR-T的表型动态变化可以作为评估免疫治疗效果的生物标志物。这一发现为临床监测癌症治疗进展提供了一种微创且高效的手段。References:Ito K, Iida K, Hirano T, et al. Phenotype of circulating tumor-reactive T cells predicts immune checkpoint inhibitor response in non-small cell lung cancer[J]. Nature Communications, 2026, 17(1): 2856.前往小宇宙评论区与主播互动
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1636-外周血肿瘤反应性T细胞表型预测肺癌免疫疗效
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