EPISODE · Oct 2, 2026 · 23 MIN
1638-基于质子泵驱动酸度的多尺度成像评估肿瘤进展与转移
from 聊聊Sci
这项研究介绍了一种pH响应型比例光声传感器（PPS），专门用于高灵敏度地监测肝细胞癌（HCC）的发生、发展及转移。研究人员发现ATP6V0C蛋白是驱动肿瘤微环境酸化的核心分子，并以此作为生物标志物来评估癌症的恶性程度。通过光声分子成像技术，该传感器能够突破传统影像限制，在深层组织中精确勾勒肿瘤边界并追踪淋巴结转移。此外，PPS不仅能通过酸激活实现光热治疗，还能与质子泵抑制剂联合使用，通过调节酸性环境产生协同抗癌效果。这项成果为癌症的早期诊断和微环境靶向治疗提供了一种全新的精准医疗策略。References:Zeng S, Chen J, Ren Y, et al. Multiscale imaging on proton pump-driven acidity for assessing tumor progression and metastasis[J]. Nature Communications, 2026, 17(1): 1785.前往小宇宙评论区与主播互动
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1638-基于质子泵驱动酸度的多尺度成像评估肿瘤进展与转移
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