164 - Strategic Approaches to Impurity Control in Multi-Step Organic Syntheses (S11E14)

This episode explores the common sources of impurities in complex organic syntheses for drug development. What analytic techniques and process controls are implemented is gone over. There is a deep dive on all the ways impurities can take form. Materials that can cause it and other things that can stop the final solution.Where they have a focus. Techniques to find and measure them is highlighted, such as ways to keep tabs on everything. Where that's all leading too, different regulatory standards and what happens is explained. A discussion on analytical testing follows in short order.