EPISODE · Oct 3, 2026 · 20 MIN
1640-人脑髓系细胞在衰老与阿尔茨海默病中的可塑性
from 聊聊Sci
这份研究通过对1,600多名捐赠者、超过83万个单细胞进行测序，构建了一个大规模的人类大脑髓系细胞图谱。科学家们在额叶皮层中鉴定出13种功能各异的亚型，涵盖了稳态、适应性及与阿尔茨海默病（AD）相关的小胶质细胞。研究重点发现了一种名为GPNMB的特定亚型，其数量随AD病情加重而显著增加，并展现出极强的吞噬活性。通过整合遗传学与转录组数据，研究确认了MITF是维持该病理亚型的关键上游调节因子。此外，分析还揭示了TREM2在介导神经保护作用及细胞间通讯中的核心地位。这些发现深化了对老龄化与阿尔茨海默病中免疫细胞演变的理解，并为开发新的治疗策略提供了分子靶点。References:Lee D, Vicari J M, Porras C, et al. Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer’s disease[J]. Nature Genetics, 2026, 58(9): 2152-2163.前往小宇宙评论区与主播互动
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1640-人脑髓系细胞在衰老与阿尔茨海默病中的可塑性
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