EPISODE · Sep 28, 2026 · 22 MIN
1655-肿瘤免疫微环境重塑预测免疫检查点抑制剂疗效
from 聊聊Sci
该研究通过构建涵盖10种癌症类型的大规模纵向单细胞转录组图谱，系统性地揭示了肿瘤免疫微环境（TIME）在接受免疫检查点抑制剂（ICI）治疗过程中的动态重塑机制。研究人员鉴定出四种跨癌种保守的免疫微环境亚型，并发现相比于单一的基调状态，微环境在治疗期间的状态转换方向能更精准地预测患者的临床疗效。具体而言，向B细胞富集或炎症状态的转变预示着良好的治疗反应，而向骨髓细胞主导的转化则与耐药性相关。基于这些动态特征，团队进一步开发了一个包含59个基因的基线签名，为临床预判免疫治疗的响应和生存率提供了全新的分子预测工具。研究强调，将肿瘤免疫环境视为一个演化的动态系统，对于优化个性化免疫治疗策略具有至关重要的意义。References:Lin Z, Chandra M, Srinivas N, et al. Tumor immune microenvironment remodeling predicts response to checkpoint inhibitor therapy[J]. Cancer cell, 2026.前往小宇宙评论区与主播互动
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1655-肿瘤免疫微环境重塑预测免疫检查点抑制剂疗效
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