EPISODE · Oct 11, 2025 · 56 MIN
168. Chemistry, Evolved
from People I (Mostly) Admire · host Freakonomics Radio + Stitcher
Frances Arnold pioneered the process of directed evolution — mimicking natural selection to create new enzymes that have changed everything from agriculture to laundry. SOURCES:Frances Arnold, professor of chemistry at the California Institute of Technology. RESOURCES: "Innovation by Evolution: Bringing New Chemistry to Life," by Frances Arnold (Nobel Lecture, 2018)."Bacteria taught to bond carbon and silicon for the first time," by Aviva Rutkin (New Scientist, 2016)."Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life," by S. B. Jennifer Kan, Russell D. Lewis, Kai Chen, and Frances H. Arnold (Science, 2016)."The Director of Evolution," by Jennifer Ouellette (Slate, 2013)."Engineered ketol-acid reductoisomerase and alcohol dehydrogenase enable anaerobic 2-methylpropan-1-ol production at theoretical yield in Escherichia coli," by Sabine Bastian, Xiang Liu, Joseph T. Meyerowitz, Christopher D. Snow, Mike M. Y. Chen, and Frances H. Arnold (Metabolic Engineering, 2011).Gevo.Provivi. EXTRAS:"How to Help Kids Succeed," by People I (Mostly) Admire (2025).The Levitt Lab. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
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Frances Arnold pioneered the process of directed evolution — mimicking natural selection to create new enzymes that have changed everything from agriculture to laundry.
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168. Chemistry, Evolved
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