171: Fragile X Syndrome Day: Clinical Challenges, Care Strategies, and Emerging Therapies

Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice.In episode 171, “Fragile X Syndrome Day: Clinical Challenges, Care Strategies, and Emerging Therapies,” Craig A. Erickson, MD, professor of psychiatry at Cincinnati Children’s Hospital, discussed the evolving landscape of Fragile X syndrome (FXS) care in honor of National Fragile X Syndrome Day. Erickson reviewed current challenges in recognizing and diagnosing FXS. He also underscored the importance of genetic testing and outlined key counseling points for families once a diagnosis is confirmed.Erickson, who also serves as the director of the Cincinnati Fragile X Research and Treatment Center, provided an overview of behavioral and neuropsychiatric management across the lifespan. He highlighted evidence-informed approaches for ADHD, irritability and aggression, and anxiety, as well as the critical role of early intervention and structured supports in adulthood. The discussion closed with a look at emerging therapeutics and how these advances may reshape clinical practice and long-term outcomes for individuals with FXS.Looking for more Genetic Disorders discussion? Check out the NeurologyLive® Genetic Disorders clinical focus page.Episode Breakdown: 1:25 – Challenges in recognizing and diagnosing Fragile X  3:25 – Genetic counseling and cascade testing after diagnosis  6:00 – Managing behavioral and neuropsychiatric symptoms  9:55 – News Minute  12:45 – Clinical management across the lifespan  17:12 – Emerging therapies and research priorities  21:17 – Why Fragile X awareness remains critical  The stories featured in this week’s Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: FDA Accepts BLA for Z-Rostudirsen in DMD, Sets January PDUFA Date FDA Accepts NDA for Apnimed’s AD109 for the Treatment of Obstructive Sleep Apnea FDA Accepts NDA for Axsome Therapeutics’ AXS-12 for the Treatment of Cataplexy in Narcolepsy Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.