171: Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier?

Danchuk S et al., Proceedings of the National Academy of Sciences - Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier? Music:Enjoy the music based on this article at the end of the episode. Article title:Virulence hierarchies within theMycobacterium tuberculosiscomplex First author:Danchuk S Journal:Proceedings of the National Academy of Sciences DOI:10.1073/pnas.2507104122 Reference:Danchuk S.N., Duffy S.C., Sullivan J., Beenish Rufai S., McIntosh F.A., Lupien A., et al.. Virulence hierarchies within theMycobacterium tuberculosiscomplex. Proceedings of the National Academy of Sciences, 122. (2025). https://doi.org/10.1073/pnas.2507104122 Support:Base by Base – Stripe donations: https://donate.stripe.com/7sY4gz71B2sN3RWac5gEg00 Official website https://basebybase.com On PaperCast Base by Base you'll discover the latest in genomics, functional genomics, structural genomics, and proteomics. Episode link: https://basebybase.com/episodes/virulence-hierarchies-in-the-tuberculosis-complexwhat-makes-some-lineages-deadlier Chapters (00:00:00) - Virulence hierarchies within the Mycobacterium Tu(00:03:17) - Fighting mbovin in the calf(00:06:05) - M. Bovis vs Amorgis TB pathogenesis(00:09:58) - MTBC virulence and the big mystery(00:11:52) - Immunity studies of human TB(00:13:48) - Animal-adapted TB