#17A - Antipsychotics: the First Principles of pathways

The First Principles of Antipsychotics that can more than get you through your psychiatry rotation: is it all about the dopamine? === Other Links === Check out our new website ⁠⁠⁠1pm.wiki⁠⁠⁠ for the ⁠⁠⁠Notion document⁠⁠⁠, free Anki flashcards, and podcast episodes. Check out our Instagram: ⁠⁠⁠https://www.instagram.com/firstprinciplesofmedicine/⁠⁠⁠ Recorded 7 March 2023 Co-hosts: Broska Zeynel & Jason D'Silva feat. Renae Long & Alexander Lawrie. Produced by Adian Izwan. If you have any ideas or feedback, comment on this Notion document, or shoot us an email at ⁠⁠⁠[email protected]⁠⁠⁠ *** We’re really excited to be collaborating with Becky from Becky’s notes, a UK based resource, to produce infographics for our visual learners out there. Becky’s notes brings together all the key topics medical students need to know in a readily available place, reviewed by specialists in the field. These visually striking notes are a refreshing change from all the boring textbooks. You can check her out on Instagram at @beckysnotes01 and get her books at ⁠⁠⁠https://linktr.ee/Beckysnotes⁠⁠⁠ === Timestamps === (01:33) The First Principles of pathways (02:59) Dopaminergic pathways (03:28) Mesolimbic - positive symptoms (04:13) Mesocortical - negative symptoms (07:17) Nigrostriatal - motor symptoms (08:15) Tuberoinfundibular - prolactin (09:06) Pathway summary (10:53) Other receptors (13:47) Antipsychotics (finally) (14:19) Typical antipsychotics (17:43) Negative symptoms mnemonic (19:36) Neuroleptic malignant syndrome (22:28) Atypical antipsychotics (24:23) Metabolic side effects (25:07) Summary