#18 Pt1: Your Genes Run Your Perimenopause — The 3 Hormonal Archetypes

Send us Fan MailEpisode descriptionYulia Mintchin, Forbes 30 Under 30 entrepreneur and creator of FemGene, reveals why perimenopause is an epigenetic reprogramming event — not just a hormone dip — and how genetic testing can predict your symptoms and HRT response before a single prescription is writtenKey topics discussed Perimenopause as a communication breakdown between genes and hormones  Why women were excluded from medical research and what that means today  Hormone genomics and hormone genetics — a new medical category  The three hormonal archetypes: Sensitive, Silent and Resilient  The COMT gene variant and oestrogen clearance, affecting around 20% of the population  Why HRT fails for 40% of women — and how FemGene aims to fix that  Hormone metabolites vs hormone levels: the missing safety step  Bioidentical vs synthetic oestrogen — the cherry Haribo analogy  Endometriosis case study: progesterone and halted progression  Oncology’s shifting stance on HRT and oestrogen during cancer treatment  The WHI study and tamoxifen: historical context Timestamps00:00 Why perimenopause may be about genetic response, not just hormone decline 01:00 Meet Yulia Mintchin and the FemGene thesis 03:10 Why perimenopause is medicine’s biggest blind spot 05:05 Hormone genomics and hormone genetics explained 14:15 The three hormonal archetypes: Sensitive, Silent and Resilient 23:05 Why doubling HRT doses can backfire 24:10 COMT, oestrogen clearance and personalisation 31:40 When women should start testing 33:20 Endometriosis case study: progesterone and progression 37:20 How archetypes change HRT decisions 41:05 What the FemGene process looks like 45:00 Bioidentical vs synthetic oestrogen 51:20 Red flags that HRT is being managed poorly 56:05 Oncology, HRT and shifting views on oestrogen 58:10 Outro and disclaimerReferences and resources mentioned FemGene hormone genomic test — via Will Be: https://www.mywillbe.co.uk/ The WHI (Women’s Health Initiative) study — landmark trial that shaped HRT policy  Biohacking Eve episode with Jennifer Garrison, referenced as approximately Episode 1, on hormonal changes affecting 80% of body systems  COMT gene and oestrogen metabolism — widely studied SNP; Yulia references the slow COMT variant  Tamoxifen and breast cancer treatment — historical context discussed Guest social links Instagram: https://www.instagram.com/yulia.mintchin/ LinkedIn: https://www.linkedin.com/in/yuliamintchin/ Will Be website: https://www.mywillbe.co.uk/Insta/TikTok: @BiohackingEveWebsite: www.BiohackingEve.com