EPISODE · Oct 29, 2025 · 54 MIN
192-蠕脂纤维母细胞驱动克罗恩病肠道纤维化
from 聊聊Sci
这篇文章概述了蠕动脂肪（CF）在克罗恩病（CD）导致的肠道狭窄中的作用。研究人员发现，一种促纤维化、机械敏感的CTHRC1+成纤维细胞群源自蠕动脂肪，并通过YAP/TAZ信号传导促进肠道纤维化。通过结合人类单细胞图谱和小鼠模型，该研究确定了这些成纤维细胞是纤维化的关键来源，并提出通过靶向蠕动脂肪来治疗克罗恩病狭窄的可能性。References: Bauer-Rowe, Khristian E., et al. "Creeping fat-derived mechanosensitive fibroblasts drive intestinal fibrosis in Crohn’s disease strictures." Cell (2025).前往小宇宙评论区与主播互动
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192-蠕脂纤维母细胞驱动克罗恩病肠道纤维化
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