EPISODE · Oct 30, 2025 · 29 MIN
195-wellDR-seq解码乳腺癌的基因组和转录组进展
from 聊聊Sci
这份研究介绍了一种名为 wellDR-seq 的高分辨率、高通量单细胞测序方法，该方法能够同时分析单个细胞的全基因组和转录组。研究人员将这项技术应用于雌激素受体阳性（ER+）乳腺癌样本，以探究拷贝数变异（CNAs）与基因表达之间的复杂关系。通过对12名患者的分析，研究确定了 Luminal 激素反应性细胞 是某些 ER+ 乳腺癌的潜在起源细胞，并揭示了近 56% 的拷贝数变异片段与基因表达存在近似线性相关性，从而区分出剂量敏感和剂量不敏感基因，极大地增进了对乳腺癌进展机制的理解。References: Wang, Kaile, et al. "Coalescing single-cell genomes and transcriptomes to decode breast cancer progression." Cell (2025).前往小宇宙评论区与主播互动
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195-wellDR-seq解码乳腺癌的基因组和转录组进展
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