196: Impact of Chromatin Accessibility QTLs Across Immune Contexts

Impact of Chromatin Accessibility QTLs Across Immune Contexts Music:Enjoy the music based on this article at the end of the episode. License:This episode is based on an open-access article published under the Creative Commons Attribution 4.0 International License (CC BY 4.0) – https://creativecommons.org/licenses/by/4.0/ Support:Base by Base – Stripe donations: https://donate.stripe.com/7sY4gz71B2sN3RWac5gEg00 Official website https://basebybase.com On PaperCast Base by Base you’ll discover the latest in genomics, functional genomics, structural genomics, and proteomics. Episode link: https://basebybase.com/episodes/impact-of-chromatin-accessibility-qtls-across-immune-contexts QC:This episode was checked against the original article PDF and publication metadata for the episode release published on 2025-11-12. QC Scope:- article metadata and core scientific claims from the narration- excludes analogies, intro/outro, and music- transcript coverage: Audited core caQTL biology and context: PBMC-wide caQTL mapping; dynamic caQTLs along cell trajectories; COVID-19 contexts and heritability enrichment; caQTL–eQTL–GWAS integration; ABC-based distal linking; CARD9 case in monocytes; emphasis on triple convergence for causal inference.- transcript topics: Single-cell caQTL mapping in PBMCs across healthy, COVID-19, convalescent; caQTL–eQTL–GWAS integration and interpretability; Topic modeling and cell-state trajectories of caQTLs; Dynamic caQTLs during activation (k17 CD8 TEM); COVID-19 cellular context and heritability enrichment; Distal caQTLs and ABC-based enhancer–gene linking QC Summary:- factual score: 10/10- metadata score: 10/10- supported core claims: 6- claims flagged for review: 0- metadata checks passed: 4- metadata issues found: 0 Metadata Audited:- article_doi- article_title- article_journal- license Factual Items Audited:- caQTL count across PBMCs: 37,390- dynamic caQTLs identified: 4,200- caQTL sharing: less than 20% confined to a single context- increase in GWAS-loci explainable when incorporating caQTLs (from ~32.9% to ~57.3%)- COVID-19 cell-state k17 enriched for disease-relevant heritability (severe COVID-19)- triple convergence (GWAS locus + caQTL + eQTL) in the same cellular context QC result: Pass.