EPISODE · Oct 30, 2025 · 21 MIN
196-TET2突变增强巨噬细胞抗原呈递与免疫治疗效果
from 聊聊Sci
这篇文章主要探讨了TET2突变型克隆性造血（CH）在实体瘤免疫治疗中的作用。研究人员使用小鼠模型和人类患者队列数据，发现具有TET2突变的巨噬细胞在干扰素-γ（IFNγ）存在下表现出更强的抗原呈递能力，并能更有效地交叉启动CD8+ T细胞。这些发现表明，TET2-CH通过促进促炎性肿瘤免疫微环境，显著改善了对免疫检查点疗法的反应，特别是对非小细胞肺癌和结直肠腺癌患者而言，TET2-CH可作为预测治疗效果的潜在生物标志物。References: Herbrich, Shelley, et al. "TET2-mutant clonal hematopoiesis enhances macrophage antigen presentation and improves immune checkpoint therapy in solid tumors." Cancer Cell (2025).前往小宇宙评论区与主播互动
Embed this episode
Ready to play
196-TET2突变增强巨噬细胞抗原呈递与免疫治疗效果
0:00
21:06
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Forfeiture Book Review: Ecocide and Sci-Fi
JP et al.
A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra
Deep Dream State
Neural Nets And Pretty Patterns
Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 21 minutes long.
When was this 聊聊Sci episode published?
This episode was published on October 30, 2025.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!