2 10 2025

Hi, This Week in Medicine, we will be discussing First we will be discussing articles in New England Journal of MedicineAlternative Complement Pathway Inhibition with Iptacopan in IgA Nephropathy Atrasentan in Patients with IgA Nephropathy Efficacy of Zenocutuzumab in NRG1 Fusion–Positive Cancer Journal of  American Medical AssociationSimvastatin and Rifaximin in Decompensated CirrhosisA Randomized Clinical Trial Age and Sex Differences in Efficacy of Treatments for Type 2 DiabetesA Network Meta-Analysis  Annals of Internal MedicineEffectiveness and Cost-Effectiveness of Expanded Targeted Testing and Treatment of Latent Tuberculosis Infection Among the Medicare Population in 2022 British Medical JournalFrozen versus fresh embryo transfer in women with low prognosis for IVF treatment LancetTraumatic injury mortality in the Gaza Strip from Oct 7, 2023, to June 30, 2024: a capture–recapture analysis  Journal of Clinical OncologyOPAR: A Randomized Trial of Partial Breast Irradiation in Five Fractions Once Daily for Early Breast Cancer  HepatologyACMSD inhibition corrects fibrosis, inflammation, and DNA damage in MASLD/MASH Gastroenterology Obesity-Facilitated Colon Cancer Progression Is Mediated by Increased Diacylglycerol O-Acyltransferases 1 and 2 Levels Clinical Gastroenterology Satisfaction With and Adherence to Off-Label Corticosteroids in Adolescents and Adults With Eosinophilic Esophagitis: Results of a Web-Based Survey in the United States Clinical Infectious DiseasesAntibiotic Prescribing for Respiratory Tract Infections in Urgent Care: A Comparison of In-Person and Virtual Settings  Rheumatology Use of 18F-fluorodeoxyglucose Positron Emission Tomography to Monitor Disease Activity in Patients With Giant Cell Arteritis on Tocilizumab Journal of Clinical Rheumatology  Nationwide Analysis of Variables Associated With Sarcoid Inpatient Mortality CirculationLarge-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis in the Management of Intermediate-Risk Pulmonary Embolism: Primary Results of the PEERLESS Randomized Controlled Trial  Journals of the American College of CardiologySecondary Prevention Medications in 17 Countries Grouped by Income Level (PURE): A Prospective Cohort Study JAMA CardiologyMicroaxial Flow Pump Hemodynamic and Metabolic Effects in Infarct-Related Cardiogenic ShockA Substudy of the DanGer Shock Randomized Clinical Trial Insulin Sensitivity and Insulin Secretion in Adults With Friedreich's Ataxia: The Role of Skeletal Muscle  Diabetes careLarge Language Model GPT-4 Compared to Endocrinologist Responses on Initial Choice of Glucose-Lowering Medication Under Conditions of Clinical Uncertainty  NeurologyEffect of IV Thrombolysis With Alteplase in Patients With Vessel Occlusion in the WAKE-UP Trial   ChestA 1-Year Weight Management Program for Difficult-to-Treat Asthma With ObesityA Randomized Controlled Study The American Journal of Respiratory and Critical Care MedicineType 1 Immune Responses Related to Viral Infection Influence Corticosteroid Response in Asthma  Clinical Journal of American Society of NephrologyMedication Burden and Adverse Cardiovascular Events and Death in Patients Treated with Maintenance Hemodialysis: A Nationwide Cohort Study Kidney International reportsImplementation of a Kidney Genetic Service Into the Diagnostic Pathway for Patients With Chronic Kidney Disease in Canada clinical utility, strategies to reduce the time from CKD diagnosis to genetics assessment are needed.