2 10 2025

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Alternative Complement Pathway Inhibition with Iptacopan in IgA Nephropathy

Atrasentan in Patients with IgA Nephropathy

Efficacy of Zenocutuzumab in NRG1 Fusion–Positive Cancer

 Journal of  American Medical Association

Simvastatin and Rifaximin in Decompensated Cirrhosis

A Randomized Clinical Trial

Age and Sex Differences in Efficacy of Treatments for Type 2 Diabetes

A Network Meta-Analysis

  Annals of Internal Medicine

Effectiveness and Cost-Effectiveness of Expanded Targeted Testing and Treatment of Latent Tuberculosis Infection Among the Medicare Population in 2022

 British Medical Journal

Frozen versus fresh embryo transfer in women with low prognosis for IVF treatment

 Lancet

Traumatic injury mortality in the Gaza Strip from Oct 7, 2023, to June 30, 2024: a capture–recapture analysis

  Journal of Clinical Oncology

OPAR: A Randomized Trial of Partial Breast Irradiation in Five Fractions Once Daily for Early Breast Cancer

  Hepatology

ACMSD inhibition corrects fibrosis, inflammation, and DNA damage in MASLD/MASH

 Gastroenterology

Obesity-Facilitated Colon Cancer Progression Is Mediated by Increased Diacylglycerol O-Acyltransferases 1 and 2 Levels

 Clinical Gastroenterology

Satisfaction With and Adherence to Off-Label Corticosteroids in Adolescents and Adults With Eosinophilic Esophagitis: Results of a Web-Based Survey in the United States

 Clinical Infectious Diseases

Antibiotic Prescribing for Respiratory Tract Infections in Urgent Care: A Comparison of In-Person and Virtual Settings

  Rheumatology 

Use of 18F-fluorodeoxyglucose Positron Emission Tomography to Monitor Disease Activity in Patients With Giant Cell Arteritis on Tocilizumab

 Journal of Clinical Rheumatology 

 Nationwide Analysis of Variables Associated With Sarcoid Inpatient Mortality

Circulation

Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis in the Management of Intermediate-Risk Pulmonary Embolism: Primary Results of the PEERLESS Randomized Controlled Trial

 Journals of the American College of Cardiology

Secondary Prevention Medications in 17 Countries Grouped by Income Level (PURE): A Prospective Cohort Study

 JAMA Cardiology

Microaxial Flow Pump Hemodynamic and Metabolic Effects in Infarct-Related Cardiogenic ShockA Substudy of the DanGer Shock Randomized Clinical Trial

Insulin Sensitivity and Insulin Secretion in Adults With Friedreich's Ataxia: The Role of Skeletal Muscle 

 Diabetes care

Large Language Model GPT-4 Compared to Endocrinologist Responses on Initial Choice of Glucose-Lowering Medication Under Conditions of Clinical Uncertainty

 Neurology

Effect of IV Thrombolysis With Alteplase in Patients With Vessel Occlusion in the WAKE-UP Trial

  Chest

A 1-Year Weight Management Program for Difficult-to-Treat Asthma With Obesity

A Randomized Controlled Study

The American Journal of Respiratory and Critical Care Medicine

Type 1 Immune Responses Related to Viral Infection Influence Corticosteroid Response in Asthma

 Clinical Journal of American Society of Nephrology

Medication Burden and Adverse Cardiovascular Events and Death in Patients Treated with Maintenance Hemodialysis: A Nationwide Cohort Study

 Kidney International reports

Implementation of a Kidney Genetic Service Into the Diagnostic Pathway for Patients With Chronic Kidney Disease in Canada

 clinical utility, strategies to reduce the time from CKD diagnosis to genetics assessment are needed.