2 3 2025

Hi, This Week in Medicine, we will be discussing First we will be discussing articles in New England Journal of MedicineTirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity Continuation versus Interruption of Oral Anticoagulation during TAVI Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A CRISPR-Based Therapy for Hereditary Angioedema  Journal of  American Medical AssociationHealth System, Community-Based, or Usual Dementia Care for Persons With Dementia and Caregivers Palliative Care Program for Community-Dwelling Individuals With Dementia and CaregiversThe IN-PEACE Randomized Clinical Trial Annals of Internal MedicineThe Association of Epstein–Barr Virus Donor and Recipient Serostatus With Outcomes After Kidney Transplantation British Medical Journal Frozen versus fresh embryo transfer in women with low prognosis for in vitro fertilisation treatment: pragmatic, multicentre, randomised controlled trial  LancetCoronary CT angiography-guided management of patients with stable chest pain: 10-year outcomes from the SCOT-HEART randomised controlled trial in Scotland  Journal of Clinical OncologyIncidence of Medication-Related Osteonecrosis of the Jaw in Patients With Breast Cancer During a 20-Year Follow-Up: A Population-Based Multicenter Retrospective Study journal of HepatologyPatient-reported outcomes in chronic hepatitis delta: An exploratory analysis of the phase III MYR301 trial of bulevirtide outcome following liver transplantation of patients with ACLF grade 3  GastroenterologyMyosin Vb Traffics P-Glycoprotein to the Apical Membrane of Intestinal Epithelial Cells Clinical Gastroenterology Prevalence and Predictors of Follow-up Endoscopic Biopsy in Patients With Celiac Disease in the United States Do Patients With NASH-related Cirrhosis Have Better Overall Survival Compared With Other Etiologies of Cirrhosis? A Population-based Study  Rheumatology Associations of fire smoke and other pollutants with incident rheumatoid arthritis and rheumatoid arthritis‐associated interstitial lung disease CirculationEfficacy and Safety of Finerenone Across the Ejection Fraction Spectrum in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Prespecified Analysis of the FINEARTS-HF Trial  Journals of the American College of CardiologyMachine Learning-Based Prediction of Death and Hospitalization in Patients With Implantable Cardioverter Defibrillators  JAMA CardiologyArtificial Intelligence–Enhanced Electrocardiography for Prediction of Incident Hypertension Journal of Clinical Endocrinology & MetabolismCausal Association Between BMI and Polycystic Ovarian Syndrome: Bidirectional 2-Sample Mendelian Randomization Study Diabetes careGlycemic and Psychosocial Outcomes of Advanced Hybrid Closed-Loop Therapy in Youth With High HbA1c: A Randomized Clinical Trial ChestLongitudinal Changes in Maximal Forced Inspiratory Flow and Clinical Outcomes in Patients With COPD The American Journal of Respiratory and Critical Care MedicineToll-like Receptor 9 Inhibition Mitigates Fibroproliferative Responses in Translational Models of Pulmonary Fibrosis Clinical Journal of American Society of NephrologySodium-Glucose Cotransporter 2 Inhibitors and Kidney Outcomes across the Spectrum of Kidney Disease: A Systematic Review and Meta-Analysis Cost-Effectiveness of Empagliflozin in CKD with or without Albuminuria Kidney International reportsRandomized Trial Demonstrating No Translocation of Intact Intestinal Bacteria During Hemodialysis or Hemodiafiltration