2 3 2025

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity

Continuation versus Interruption of Oral Anticoagulation during TAVI

Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A

CRISPR-Based Therapy for Hereditary Angioedema

  Journal of  American Medical Association

Health System, Community-Based, or Usual Dementia Care for Persons With Dementia and Caregivers

Palliative Care Program for Community-Dwelling Individuals With Dementia and Caregivers

The IN-PEACE Randomized Clinical Trial

 Annals of Internal Medicine

The Association of Epstein–Barr Virus Donor and Recipient Serostatus With Outcomes After Kidney Transplantation

 British Medical Journal

Frozen versus fresh embryo transfer in women with low prognosis for in vitro fertilisation treatment: pragmatic, multicentre, randomised controlled trial

  Lancet

Coronary CT angiography-guided management of patients with stable chest pain: 10-year outcomes from the SCOT-HEART randomised controlled trial in Scotland

 Journal of Clinical Oncology

Incidence of Medication-Related Osteonecrosis of the Jaw in Patients With Breast Cancer During a 20-Year Follow-Up: A Population-Based Multicenter Retrospective Study

 journal of Hepatology

Patient-reported outcomes in chronic hepatitis delta: An exploratory analysis of the phase III MYR301 trial of bulevirtide

 outcome following liver transplantation of patients with ACLF grade 3

  Gastroenterology

Myosin Vb Traffics P-Glycoprotein to the Apical Membrane of Intestinal Epithelial Cells

 Clinical Gastroenterology

 Prevalence and Predictors of Follow-up Endoscopic Biopsy in Patients With Celiac Disease in the United States

Do Patients With NASH-related Cirrhosis Have Better Overall Survival Compared With Other Etiologies of Cirrhosis? A Population-based Study

  Rheumatology 

Associations of fire smoke and other pollutants with incident rheumatoid arthritis and rheumatoid arthritis‐associated interstitial lung disease

 Circulation

Efficacy and Safety of Finerenone Across the Ejection Fraction Spectrum in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Prespecified Analysis of the FINEARTS-HF Trial

  Journals of the American College of Cardiology

Machine Learning-Based Prediction of Death and Hospitalization in Patients With Implantable Cardioverter Defibrillators

  JAMA Cardiology

Artificial Intelligence–Enhanced Electrocardiography for Prediction of Incident Hypertension

 Journal of Clinical Endocrinology & Metabolism

Causal Association Between BMI and Polycystic Ovarian Syndrome: Bidirectional 2-Sample Mendelian Randomization Study

 Diabetes care

Glycemic and Psychosocial Outcomes of Advanced Hybrid Closed-Loop Therapy in Youth With High HbA1c: A Randomized Clinical Trial

 Chest

Longitudinal Changes in Maximal Forced Inspiratory Flow and Clinical Outcomes in Patients With COPD

 The American Journal of Respiratory and Critical Care Medicine

Toll-like Receptor 9 Inhibition Mitigates Fibroproliferative Responses in Translational Models of Pulmonary Fibrosis

 Clinical Journal of American Society of Nephrology

Sodium-Glucose Cotransporter 2 Inhibitors and Kidney Outcomes across the Spectrum of Kidney Disease: A Systematic Review and Meta-Analysis

Cost-Effectiveness of Empagliflozin in CKD with or without Albuminuria

 Kidney International reports

Randomized Trial Demonstrating No Translocation of Intact Intestinal Bacteria During Hemodialysis or Hemodiafiltration