2 5 2024

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Live, Attenuated, Tetravalent Butantan–Dengue Vaccine in Children and Adults

Skin Antisepsis before Surgical Fixation of Extremity Fractures

Trial of N-Acetyl-l-Leucine in Niemann–Pick Disease Type C

CRISPR-Cas9 In Vivo Gene Editing of KLKB1 for Hereditary Angioedema

  Journal of  American Medical Association

Neurodevelopmental Outcomes of Extremely Preterm Infants Fed Donor Milk or Preterm Infant Formula

Functional Outcomes After Localized Prostate Cancer Treatment

  Nature Medicine

First-line sugemalimab with chemotherapy for advanced esophageal squamous cell carcinoma: a randomized phase 3 study

  British Medical Journal

Atypia detected during breast screening and subsequent development of cancer: observational analysis of the Sloane atypia prospective cohort in England

 Lancet

Conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU): a UK multicentre, open, parallel-group, randomised clinical trial

  Journal of Clinical Oncology

Omission of Radiotherapy After Breast-Conserving Surgery for Women With Breast Cancer With Low Clinical and Genomic Risk: 5-Year Outcomes of IDEA

  journal of Hepatology

Adjusted estimate of the prevalence of hepatitis delta virus in 25 countries and territories

 Clinical Gastroenterology

Real-World Efficacy of Dupilumab in Severe, Treatment-Refractory, and Fibrostenotic Patients With Eosinophilic Esophagitis

 endent Female Survival Advantage in Hepatocellular Carcinoma: A Multicenter Cohort Study

  Arthritis and Rheumatology

Kidney Outcomes and Preservation of Kidney Function With Obinutuzumab in Patients With Lupus Nephritis: A Post Hoc Analysis of the NOBILITY Trial

  Circulation

Efficacy, Safety, and Tolerability of Inclisiran in Patients With Homozygous Familial Hypercholesterolemia: Results From the ORION-5 Randomized Clinical Trial

American College of Cardiology

CRP Modifies Lp(a)-Related Risk for CHD

 Journals of the American College of Cardiology

Outcomes According to Coronary Revascularization Modality in the ISCHEMIA Trial

 Journal of Clinical Endocrinology & Metabolism

Prevalence, Risk Factors, and Clinical and Biochemical Characteristics of Alemtuzumab-Induced Graves Disease 

Tirzepatide Immunogenicity on Pharmacokinetics, Efficacy, and Safety: Analysis of Data From Phase 3 Studies 

  Neurology:

Association Between Hippocampal Volumes and Cognition in Cerebral Amyloid Angiopathy

Bisphosphonates in Glucocorticoid-Treated Patients With Duchenne Muscular Dystrophy: A Systematic Review and Grading of the Evidence

 Chest

Is Tobacco Use Associated With Risk of Recurrence and Mortality Among People With TB?

 The American Journal of Respiratory and Critical Care Medicine

Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma

 Clinical Gastroenterology AND Hepatology

Real-World Efficacy of Dupilumab in Severe, Treatment-Refractory, and Fibrostenotic Patients With Eosinophilic Esophagitis

Hepatocellular Carcinoma Surveillance Patterns and Outcomes in Patients With Cirrhosis

  Clinical and Translational Gastroenterology 

Development and Validation of Serum Markers as Noninvasive Diagnostic Methods for Achalasia

 Clinical Kidney  Journal 

Differentiating primary and secondary FSGS using non-invasive urine biomarkers