2 5 2024

Hi, This Week in Medicine, we will be discussingNew England Journal of MedicineLive, Attenuated, Tetravalent Butantan–Dengue Vaccine in Children and Adults Skin Antisepsis before Surgical Fixation of Extremity Fractures Trial of N-Acetyl-l-Leucine in Niemann–Pick Disease Type C CRISPR-Cas9 In Vivo Gene Editing of KLKB1 for Hereditary Angioedema  Journal of  American Medical AssociationNeurodevelopmental Outcomes of Extremely Preterm Infants Fed Donor Milk or Preterm Infant Formula Functional Outcomes After Localized Prostate Cancer Treatment  Nature MedicineFirst-line sugemalimab with chemotherapy for advanced esophageal squamous cell carcinoma: a randomized phase 3 study  British Medical JournalAtypia detected during breast screening and subsequent development of cancer: observational analysis of the Sloane atypia prospective cohort in England LancetConservative versus liberal oxygenation targets in critically ill children (Oxy-PICU): a UK multicentre, open, parallel-group, randomised clinical trial  Journal of Clinical OncologyOmission of Radiotherapy After Breast-Conserving Surgery for Women With Breast Cancer With Low Clinical and Genomic Risk: 5-Year Outcomes of IDEA  journal of HepatologyAdjusted estimate of the prevalence of hepatitis delta virus in 25 countries and territories Clinical GastroenterologyReal-World Efficacy of Dupilumab in Severe, Treatment-Refractory, and Fibrostenotic Patients With Eosinophilic Esophagitis endent Female Survival Advantage in Hepatocellular Carcinoma: A Multicenter Cohort Study  Arthritis and RheumatologyKidney Outcomes and Preservation of Kidney Function With Obinutuzumab in Patients With Lupus Nephritis: A Post Hoc Analysis of the NOBILITY Trial  CirculationEfficacy, Safety, and Tolerability of Inclisiran in Patients With Homozygous Familial Hypercholesterolemia: Results From the ORION-5 Randomized Clinical Trial American College of CardiologyCRP Modifies Lp(a)-Related Risk for CHD Journals of the American College of CardiologyOutcomes According to Coronary Revascularization Modality in the ISCHEMIA Trial Journal of Clinical Endocrinology & MetabolismPrevalence, Risk Factors, and Clinical and Biochemical Characteristics of Alemtuzumab-Induced Graves Disease  Tirzepatide Immunogenicity on Pharmacokinetics, Efficacy, and Safety: Analysis of Data From Phase 3 Studies   Neurology:Association Between Hippocampal Volumes and Cognition in Cerebral Amyloid Angiopathy Bisphosphonates in Glucocorticoid-Treated Patients With Duchenne Muscular Dystrophy: A Systematic Review and Grading of the Evidence ChestIs Tobacco Use Associated With Risk of Recurrence and Mortality Among People With TB? The American Journal of Respiratory and Critical Care MedicineAssociation Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma Clinical Gastroenterology AND HepatologyReal-World Efficacy of Dupilumab in Severe, Treatment-Refractory, and Fibrostenotic Patients With Eosinophilic Esophagitis Hepatocellular Carcinoma Surveillance Patterns and Outcomes in Patients With Cirrhosis  Clinical and Translational Gastroenterology Development and Validation of Serum Markers as Noninvasive Diagnostic Methods for Achalasia Clinical Kidney  Journal Differentiating primary and secondary FSGS using non-invasive urine biomarkers