2025 American Thyroid Association Management Guidelines for Adult Patients with Differentiated Thyroid Cancer – Part 1

In this episode, we review the ATA 2025 thyroid cancer guideline updates on tumors of uncertain malignant potential and when germline genetic testing is appropriate. Topics include:• NIFTP and related tumors with strict pathologic criteria and low malignant risk• Management pearls and pitfalls of overtreatment• Indications for germline testing (PTEN, DICER1, APC, Carney complex, Werner syndrome)• Why non-syndromic familial thyroid cancer does not justify routine testing• Screening approaches for relatives and risks of overdiagnosis• Interpreting tumor sequencing results and confirming germline variants