2025 HFSA Symposium - The Evolving Treatment Landscape in ATTR

Originally presented as a satellite symposium at the 2025 HFSA Annual Scientific Meeting in Minneapolis, this educational activity is targeted to cardiologists, neurologists, heart failure specialists, and the interprofessional team of nurse practitioners and cardiac nurses that help manage patients with transthyretin-mediated amyloidosis (ATTR). Designed as both a data intensive and a case-based practicum, this session will offer learners an expert-led appraisal of the evolving clinical trial evidence and regulatory updates for novel therapeutics in ATTR, with an emphasis on clinical best practices for treatment selection and sequencing in ATTR-CM, ATTR-PN, and ATTR of mixed phenotype, and will include an intensive review of established and emerging pharmacologic mechanisms and incisively examine how they interface with ATTR pathophysiology. CME-Pod listeners will also get a unique “glimpse beyond the cutting edge of the calculus” in a segment led by the two winners of the 1st Annual (2024) ATTR Early-Career Research Forum, in which they detail the rationale, design, results, and real-world promise of their original ATTR research projects. Finally, the session will be punctuated by an interactive and dynamic case-based discussion that equips and engages cardiologists, neurologists, and other members of the ATTR multidisciplinary and interprofessional treatment team to bridge the disconnect between clinician and patient expectations, with the overarching strategic goal of harmonizing shared decision-making, optimizing evidence-based treatment decisions, and improving outcomes across the ATTR disease continuum.To obtain CE credit for listening, complete the activity pre-test here: https://form.jotform.com/AcademyCME/24C15PreAfter the session, complete the post-test, activity evaluation, and CE credit request here: https://form.jotform.com/AcademyCME/24C15postThank you for listening to CME-Pod! We at Cornerstone hope it equips you to improve your clinical practice and better serve your patients.