2025 In Review - Movement Disorders

This comprehensive review synthesizes high-impact research from 2025 regarding movement disorders, specifically focusing on Parkinson’s disease and hereditary ataxias. The literature highlights critical clinical trial results, such as the failure of exenatide as a disease-modifying therapy and the burgeoning potential of stem cell regenerative medicine. It also identifies significant environmental risk factors, including a strong correlation between pesticide exposure near golf courses and increased disease prevalence. Furthermore, the sources examine the role of neuroinflammation as a predictor of dementia and the importance of sleep quality and cardiovascular exercise in patient management. Finally, the collection addresses diagnostic advancements in genetics and neuroimaging, offering a roadmap for more precise biomarker discovery and personalized treatment strategies.