204. Metabolic Flexibility Explained: Why Ketones May Be an Overlooked Health Marker | Dorian Greenow

Dr. Darsh Shah and Dr. Altamash Raja sit down with Dorian Greenow, founder of Keto-Mojo, for a wide-ranging conversation on ketosis, metabolic flexibility, chronic disease, and what it means to make health measurable. Dorian shares how his own experience with weight gain, depression, and discovering nutritional ketosis shaped the creation of Keto-Mojo. From the history of ketogenic diets to the difference between nutritional and therapeutic ketosis, the conversation explores food addiction, ketone testing, metabolic psychiatry, cancer research, exogenous ketones, and why the future of healthcare may depend on outcomes — not sick care. TOPICS COVERED Why keto is more than a fad diet or marketing term Dorian’s personal journey with weight loss, depression, and nutritional ketosis How Keto-Mojo began by making ketone testing more affordable The difference between nutritional ketosis and therapeutic ketosis How ketones work as both fuel and signaling molecules Emerging research on ketogenic diets for bipolar disorder, schizophrenia, and glioblastoma Protein, muscle loss, aging, and how to think about keto beyond weight loss How ultra-processed foods, sugary drinks, and food policy shape metabolic health Why healthcare should focus on outcomes instead of sick care RESOURCES MENTIONED Dorian Greenow / Keto-Mojo Website: https://keto-mojo.com/ Dorian Greenow: https://keto-mojo.com/our-team/dorian-greenow-president-founder/ MyMojoHealth Website: https://keto-mojo.com/mymojohealth/ The Art and Science of Low Carbohydrate Living by Stephen Phinney and Jeff Volek Book: https://www.amazon.com/Art-Science-Low-Carbohydrate-Living/dp/0983490708 Volek et al., “Metabolic characteristics of keto-adapted ultra-endurance runners,” Metabolism (2016) Study: https://pubmed.ncbi.nlm.nih.gov/26892521/ Campbell et al., “A pilot study of a ketogenic diet in bipolar disorder,” BJPsych Open (2025) Study: https://www.cambridge.org/core/journals/bjpsych-open/article/pilot-study-of-a-ketogenic-diet-in-bipolar-disorder-clinical-metabolic-and-magnetic-resonance-spectroscopy-findings/7AF8E2ECB765A65B03C97F770BB90BC7 Baszucki Group Metabolic Psychiatry Initiative Website: https://baszuckigroup.com/our-work/metabolic-mental-health/metabolic-psychiatry-initiative/ Metabolic Mind Website: https://www.metabolicmind.org/ Brain Energy by Dr. Chris Palmer Book: https://brainenergy.com/ Amaral et al., “A phase 1 safety and feasibility trial of a ketogenic diet plus standard of care for glioblastoma,” Scientific Reports (2025) Study: https://www.nature.com/articles/s41598-025-06675-6 Glucose ketone index / GKI Calculator Keto-Mojo: https://keto-mojo.com/glucose-ketone-index-gki/ FOLLOW US The Show Website: medicineredefined.com (https://medicineredefined.com) Instagram / X: @medredefined (https://instagram.com/medredefined) Dr. Altamash Raja Instagram: @draltraja (https://instagram.com/draltraja) LinkedIn: Altamash Raja (https://www.linkedin.com/in/altamash-raja-do-rmsk-cscs (https://www.linkedin.com/in/altamash-raja-do-rmsk-cscs-0b1a8039/)) Refining Health & Performance (https://refininghealthrx.com) Dr. Darsh Shah Instagram: @doctor.darsh (https://www.instagram.com/doctor.darsh/) LinkedIn: doctordarsh (https://www.linkedin.com/in/doctordarsh/) Ready to stop guessing and start performing? Dr. Raja is now seeing patients through his telemedicine practice — limited founding member spots available at refininghealthrx.com (https://refininghealthrx.com).