21. Fatal Colchicine Poisoning / pharmacology and clinical perspective

Join Thu & Saley as they dive into one of the most disturbing true crime cases involving a medication - the fatal poisoning of Colchicine. Learn about this ancient drug used for gout, its mechanism of action, and how a lethal dose can cause multi-organ failure. As more details emerge about Betty's tragic death planned by her husband Connor, a medical resident, the hosts will provide insight into the pharmacology and clinical aspects of the case rarely covered elsewhere. This episode not only reviews a horrific crime, but aims to educate health professionals and the public on dangerous drug interactions and the need for vigilance when admitting suspected poisoned/overdose cases. So grab your glasses - it's time to get all up in the business of this case with your Rx friends. Five Key Takeaways 1. Colchicine is an ancient medication that can be dangerous in high doses due to its effects on microtubules and signal transduction in cells, leading to multi-organ failure. 2. Pharmacists should be vigilant about dangerous medications like Colchicine and potential drug interactions that could cause toxicity. 3. Aggressive supportive care as Colchicine poisoning has no specific antidote. This involves monitoring and treating symptoms like fluid loss, respiratory distress, organ failure, arrhythmias, etc. as they develop. 4. There are typically three stages of Colchicine poisoning: Stage 1- gastrointestinal issues; Stage 2- Multi-organ failure stage; Stage 3- Recovery stage. 5. Betty Bowman was a driven, accomplished pharmacist whose tragic death highlights the importance of utter vigilance for colchicine and other medication-related toxicity ••••••••••••••••••••••••••••••••••••••••­­­••••••••••• Chapters: 00:00 Intro 00:30 Disclaimers 07:51 Betty Bowman's background 10:14 Connor Bowman's background 16:00 Clinical picture 19:52 Suspicious behaviors and evidence 37:27 Sodium nitrate? 39:56 Colchicine background 51:08 Stages of colchicine poisoning 54:33 Management of colchicine poisoning 59:24 Information about the criminal charge 1:04:38 Final thoughts ••••••••••••••••••••••••••••••••••••••••­­­••••••••••• References https://pharmacy.ks.gov/docs/librariesprovider10/disciplinary-orders/individuals/bowman-connor-1-103025-case-23-438.pdf?sfvrsn=a6927d09_3 https://www.kttc.com/2023/12/12/tracking-timeline-betty-bowmans-death/ https://www.cbsnews.com/minnesota/news/connor-bowman-murder-charge-betty-bowman-rochester/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120738/ https://www.olmstedcounty.gov/sites/default/files/2023-10/Connor%20Bowman%20Criminal%20Complaint.pdf•••• ••••••••••••••••••••••••••••••••••••­­­••••••••••• Follow us on social media ▷Hey Rx Friends, We Got This! https://linktr.ee/Heyrxfriends Instagram: https://www.instagram.com/heyrxfriendswgt TikTok: https://www.tiktok.com/@heyrxfriendswgt YouTube: Hey Rx Friends We Got This ▷Thu https://linktr.ee/empoweredpharmd Instagram: https://www.instagram.com/empowered.pharmd/ LinkedIn: https://www.linkedin.com/in/tn-empowered-pharmd Substack: https://drthurx.substack.com/ ▷Saley: Instagram: https://www.instagram.com/reziprep360 LinkedIn: https://www.linkedin.com/in/straore1 TikTok: https://www.linkedin.com/in/straore1 X: ReziPrep360 YouTube: @ReziPrep360 Business inquiries: [email protected] Disclaimer: All opinions are our own.