EPISODE · Nov 13, 2025 · 38 MIN
228-ERG驱动的前列腺癌起始与细胞环境依赖性及KMT2A和DOT1L有关
from 聊聊Sci
这篇文章调查了ERG驱动的前列腺癌（PCa）是如何发生的。作者们使用谱系追踪和单细胞分析等方法，发现ERG转位引起的前列腺癌并非起源于常见的腔细胞，而是起源于一种罕见的、共同表达腔细胞基因的基底细胞亚群（BasalLum细胞）。这些BasalLum细胞在ERG激活后，会发展成高度增殖的中间细胞（IM cells），这种状态与较差的预后相关，并最终分化为典型的腔腺癌。重要的是，研究确定了STAT3、KMT2A/MLL1和DOT1L是ERG驱动肿瘤发生所必需的因子，揭示了潜在的治疗靶点。References: Feng W, Ladewig E, Lange M, et al. ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L[J]. Nature Genetics, 2025: 1-15.前往小宇宙评论区与主播互动
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228-ERG驱动的前列腺癌起始与细胞环境依赖性及KMT2A和DOT1L有关
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