EPISODE · Nov 16, 2025 · 37 MIN
234-弥漫大B细胞淋巴瘤肿瘤微环境的多模态空间表征
from 聊聊Sci
该文章主要对弥漫性大B细胞淋巴瘤（DLBCL）的肿瘤免疫微环境进行了多模式空间分析。通过结合空间转录组学和蛋白质组学技术对78个DLBCL肿瘤样本进行研究，文章定义了七种独特的细胞生态位（CNs），这些生态位具有独特的细胞组成和细胞间通信模式，进而影响T细胞和肿瘤B细胞的功能状态。研究发现，不同解剖部位和EB病毒（EBV）感染状态的DLBCL表现出特定的生态位分布和T细胞功能差异，例如在免疫特异部位的DLBCL中，T细胞表现出细胞毒性和功能障碍的双重特征，提示了潜在的免疫治疗靶点。References: Dai Y, Kizhakeyil A, Chihara D, et al. Multi-modal spatial characterization of tumor immune microenvironments identifies targetable inflammatory niches in diffuse large B cell lymphoma[J]. Nature Genetics, 2025: 1-13.前往小宇宙评论区与主播互动
Embed this episode
Ready to play
234-弥漫大B细胞淋巴瘤肿瘤微环境的多模态空间表征
0:00
37:27
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Forfeiture Book Review: Ecocide and Sci-Fi
JP et al.
A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra
Deep Dream State
Neural Nets And Pretty Patterns
Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 37 minutes long.
When was this 聊聊Sci episode published?
This episode was published on November 16, 2025.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!