EPISODE · Nov 17, 2025 · 51 MIN
237-人源心脏-巨噬细胞类器官与心律失常疾病模型
from 聊聊Sci
这篇文章介绍了一种新颖的人类心脏-巨噬细胞类器官平台（hHMAs），该平台通过将人类多能干细胞衍生的胚胎单核细胞整合到心脏类器官中生成。研究人员利用hHMAs来模拟免疫-心脏相互作用以及心律失常等疾病，证实了组织驻留巨噬细胞（TRMPs）在心脏发育和电传导中的重要作用。通过单细胞转录组学、活体成像和蛋白质组学等多种分析，该研究深入探讨了TRMPs如何通过细胞外囊泡（EVs）和胞葬作用与心肌细胞进行交流。最后，研究者展示了在hHMAs中，慢性NLRP3炎性体激活能够诱发心房颤动的表型，提供了一个用于机制研究和药物测试的强大体外模型。References: O’Hern C, Caywood S, Aminova S, et al. Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling[J]. Cell Stem Cell, 2025.前往小宇宙评论区与主播互动
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237-人源心脏-巨噬细胞类器官与心律失常疾病模型
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