EPISODE · Nov 18, 2025 · 30 MIN
239-BST2调控中风后星形胶质细胞与小胶质细胞的相互作用
from 聊聊Sci
这篇文章介绍了星形胶质细胞在脑损伤修复中的关键作用，特别是中风后在病灶边界形成的反应性星形胶质细胞。作者通过单细胞测序和空间转录组学技术，确定了表达干扰素诱导蛋白BST2（骨髓基质细胞抗原2）的星形胶质细胞聚集在损伤边界，并将其归类为干扰素反应性星形胶质细胞。研究核心机制在于，BST2通过激活PKCβII-NF-κB信号通路，上调补体C3的表达和分泌，从而招募表达C3a受体（C3aR）的小胶质细胞。作者发现，对星形胶质细胞特异性敲除BST2，或使用BST2单克隆抗体阻断其信号传导，可以减少星形胶质细胞与小胶质细胞之间的有害串扰，减轻早期神经元损伤，并改善小鼠中风后的运动功能。 References: Zhang S, Yuan M, Zhou J, et al. BST2 expression at astrocyte borders promotes microglial recruitment via the C3/C3aR signaling[J]. Neuron, 2025. 前往小宇宙评论区与主播互动
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239-BST2调控中风后星形胶质细胞与小胶质细胞的相互作用
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