EPISODE · Aug 24, 2025 · 9 MIN
240. 工程化iPSC修复脊髓损伤
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“工程化iPSC三维神经网络修复脊髓损伤” 一文 探讨了一种利用工程化诱导多能干细胞（iPSC）三维神经网络修复脊髓损伤的新型组织工程技术。该研究通过 模仿胚胎脊髓发育过程，利用源自患者脂肪组织的基质细胞外基质（ECM）水凝胶作为支架，成功培育出具有功能性的三维脊髓运动神经元植入物。这些植入物在 体外 表现出形成密集神经网络的能力，并能分泌促进轴突生长和导向的关键ECM蛋白，同时展现出电生理活性。体内实验结果 表明，无论是在 急性 还是 慢性 脊髓损伤模型中，植入物均能 显著减轻炎症反应和神经胶质瘢痕形成，促进神经再生和轴突跨损伤部位生长，最终 改善小鼠的运动功能。这项研究为 个性化脊髓损伤治疗 提供了潜在的新途径。内容来源：https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202105694
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240. 工程化iPSC修复脊髓损伤
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