26 - Type 1 Diabetes: From autoimmune origin to cardiometabolic consequences (15 min)

Type 1 Diabetes (T1D) is an autoimmune disease that remains underrecognized, especially in adults. Once thought of as a childhood condition, nearly half of new cases are now diagnosed in adulthood. T1D can lead to serious complications, including diabetic ketoacidosis, severe hypoglycemia, and eventually cardiometabolic disease. In today’s episode, Maeson Latsko, PhD and Franklin Warren discuss the T1D screening recommendation by the American diabetes Association and how this guidance gives physicians the opportunity to provide more timely, effective interventions, increasing the possibility of preventing complications. This episode will Outline what T1D is and the prevalence of T1D in both children and adults (2:00) Recognize the risk and complications associated with delayed or missed diagnosis, including diabetic ketoacidosis and long-term organ damage (6:20) Review the latest ADA recommendations for screening and early detection of T1D (8:00) To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: November 2025 Speaker(s):  Maeson Latsko, PhD; Franklin Warren Contributor(s): Maeson Latsko, PhD; Franklin Warren; Trisha Winchester, PhD; Millicent Kee, MSN, FNP-BC   Additional Resources Quest Diagnostics Clinical Education Center [Link] T1D Autoantibody Panel Overview T1D Autoantibody Panel Test Summary FAQ: Autoantibodies and Type 1 Diabetes (T1D) Staging presymptomatic patients using Diabetes Type 1 Autoantibody Panel   Ordering information: Diabetes Type 1 Autoantibody Panel | Test Detail | Quest Diagnostics   References:   Smith R, Eisenberg S, Turner-Pfifer A, et al. We are on the verge of breakthrough cures for Type 1 Diabetes, but who are the 2 million Americans who have it? J Health Econ Outcomes Res. 2024;11(2):145-153. doi:10.36469/001c.124604 Leslie RD, Evans-Molina C, Freund-Brown J, et al. Adult-onset Type 1 Diabetes: Current understanding and challenges. Diabetes Care. 2021;44(11):2449-2456. doi:10.2337/dc21-0770 American Diabetes Association Professional Practice Committee. 2. Diagnosis and classification of Diabetes: Standards of care in diabetes-2025. Diabetes Care. 2025;48(1 Suppl 1):S27-S49. doi:10.2337/dc25-S002 Roche EF, Menon A, Gill D, Hoey H. Clinical presentation of Type 1 Diabetes. Pediatr Diabetes. 2005;6(2):75-78. doi:10.1111/j.1399-543X.2005.00110.x Phillip M, Achenbach P, Addala A, et al. Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 Type 1 Diabetes. Diabetes Care. 2024;47(8):1276-1298. doi:10.2337/dci24-0042 Krishnan S, Short KR. Prevalence and significance of cardiometabolic risk factors in children with Type 1 Diabetes. J Cardiometab Syndr. 2009;4(1):50-56. doi:10.1111/j.1559-4572.2008.00034.x Type 1 Diabetes Complications - Breakthrough T1D (https://www.breakthrought1d.org/t1d-resources/complications/) Accessed 10.28.2025