EPISODE · Nov 24, 2025 · 14 MIN
261-空间三组学绘制脑发育与神经炎症图谱
from 聊聊Sci
这篇文章详细介绍了小鼠和人类大脑发育以及神经炎症过程中细胞状态和分子机制的空间和时间动态。研究人员开发并应用了DBiT-based空间三组学技术（如空间ARP-seq和空间CTRP-seq），同时对组织切片中的表观基因组、转录组和蛋白质组进行分析。研究结果揭示了髓鞘形成在脑胼胝体中沿着内外侧双向顺序进行，并与投射神经元（PNs）的成熟度相吻合。此外，该研究还使用溶血卵磷脂（LPC）模型来映射脱髓鞘和随后的髓鞘再生过程，并发现小胶质细胞/巨噬细胞的活化和炎症反应在原发性病变和远端白质区域表现出不同的时空延迟。References: Zhang D, Rubio Rodríguez-Kirby L A, Lin Y, et al. Spatial dynamics of brain development and neuroinflammation[J]. Nature, 2025, 647(8088): 213-227.前往小宇宙评论区与主播互动
Embed this episode
Ready to play
261-空间三组学绘制脑发育与神经炎症图谱
0:00
14:23
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Forfeiture Book Review: Ecocide and Sci-Fi
JP et al.
A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra
Deep Dream State
Neural Nets And Pretty Patterns
Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 14 minutes long.
When was this 聊聊Sci episode published?
This episode was published on November 24, 2025.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!