EPISODE · Nov 24, 2025 · 12 MIN
263-肺腺癌前体病变中肺泡祖细胞与炎症微环境的协同进化
from 聊聊Sci
该文章概述了一项使用多模态空间组学技术对肺腺癌（LUAD）前体病变进行的研究，旨在理解其进展机制。研究人员通过单细胞和空间转录组学分析发现，肺泡祖细胞（如KACs或反应性肺炎细胞）是LUAD进化的最早前体，并存在于富含IL-1β信号的上皮-促炎微环境中。这种促炎微环境在癌前病变阶段更为普遍。通过在小鼠模型中靶向IL-1β，无论是单独使用还是与PD-1抑制剂联合使用，都能有效减少这些祖细胞并抑制LUAD的发生。这些发现表明，上皮-促炎微环境是LUAD早期发展的关键因素，可作为疾病早期干预的潜在靶点。 References: Peng F, Sinjab A, Dai Y, et al. Multimodal spatial-omics reveal co-evolution of alveolar progenitors and proinflammatory niches in progression of lung precursor lesions[J]. Cancer Cell, 2025. 前往小宇宙评论区与主播互动
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263-肺腺癌前体病变中肺泡祖细胞与炎症微环境的协同进化
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