EPISODE · Nov 27, 2025 · 14 MIN
270-肿瘤劫持巨噬细胞供铁以促进骨转移和贫血
from 聊聊Sci
这篇文章研究骨转移肿瘤细胞如何劫持巨噬细胞以获取营养并适应缺氧环境的科学文章。研究确定肿瘤细胞模仿红细胞前体，利用一种特殊的巨噬细胞群（iMac）获取铁，这种巨噬细胞群在骨转移生态位中含量丰富，其特征是高表达促红细胞岛（EBI）相关的基因，例如VCAM1和CD163。该研究表明，通过抑制巨噬细胞对肿瘤细胞的铁供应，可以减缓肿瘤生长并减轻癌症相关性贫血。此外，肿瘤细胞本身通过上调血红蛋白合成来适应缺氧环境，这种机制在人类骨转移样本中也有体现。References: Han Y, Sarkar H, Xu Z, et al. Tumors hijack macrophages for iron supply to promote bone metastasis and anemia[J]. Cell, 2025, 188(22): 6335-6354. e26.前往小宇宙评论区与主播互动
Embed this episode
Ready to play
270-肿瘤劫持巨噬细胞供铁以促进骨转移和贫血
0:00
14:49
1×
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
Forfeiture Book Review: Ecocide and Sci-Fi
JP et al.
A whizz bang review of the complex themes in the new ecological Sci-Fi novel, FORFEITURE by JP Nebra
Deep Dream State
Neural Nets And Pretty Patterns
Deep Dream State is a full-cast dystopian sci-fi and desire horror audio drama by Neural Nets and Pretty Patterns. As the originating work of desire horror, it locates the uncanny inside wanting itself. While conventional horror positions you against a threat, desire horror implicates you in it. The horror emerges from recognition: the realization of why characters stay, and why surrender feels like relief. Since 2017, the show has used research in dream science, surveillance studies, behavioral economics, and advertising technology to examine systems of control through immersive sound design and full-cast performance.
Frequently Asked Questions
How long is this episode of 聊聊Sci?
This episode is 14 minutes long.
When was this 聊聊Sci episode published?
This episode was published on November 27, 2025.
Can I download this 聊聊Sci episode?
Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!