#272 Neuroinflammation: Why Your Brain Is "On Fire" & How to Put It Out | Dr. Jaquel Patterson episode artwork

EPISODE · Aug 6, 2026 · 1H 2M

#272 Neuroinflammation: Why Your Brain Is "On Fire" & How to Put It Out | Dr. Jaquel Patterson

from High Performance Longevity · host Nick Urban | Longevity, Biohacking, & Performance

What if your brain fog, anxiety, and memory lapses all trace back to one thing: an inflamed brain? Naturopathic physician Dr. Jaquel Patterson, ND, MBA joins Nick Urban to explain neuroinflammation in plain language and map the root causes behind it. With 16 years of clinical experience in Lyme disease, autoimmune conditions, and integrative psychiatry, she connects the gut, hormones, chronic infections, and environmental toxins to the same inflammatory loop, and lays out how to calm it naturally. Meet our guest Dr. Jaquel Patterson is an internationally recognized naturopathic physician, three-time Amazon bestselling author, and founder and CEO of Fairfield Family Health, a multidisciplinary practice in Connecticut with 9 doctors offering telemedicine nationwide. She has a TEDx talk on root-cause medicine coming soon. Thank you to our partners Outliyr Biohacker’s Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Neuroinflammation shows up as brain fog, poor focus, memory lapses, and mood swings, an inflamed brain "on fire" The blood-brain barrier keeps out about 98% of solutes until chronic inflammation breaks it down About 90% of your serotonin is made in the gut, linking gut health directly to mood and cognition Deep sleep runs the brain's lymphatic clean-out, and sauna lowers CRP and IL-6 A standard CBC can miss iron deficiency for 3 to 6 months Curcumin downregulates IL-6, and phosphatidylserine lowers cortisol while sharpening focus Small, consistent micro-moments beat dramatic overhauls that never stick   Episode highlights 01:09 The "brain on fire" explanation 02:30 Microglia as your brain's garbage men 11:51 Leaky gut, leaky brain 17:13 Sleep and sauna to lower inflammation 27:58 The iron test most doctors skip 48:31 Curcumin for mood and IL-6 57:02 The cheapest thing you can do for your brain Links Watch it on YouTube: https://youtu.be/yWFYfc80Q1U  Full episode show notes: https://outliyr.com/272  Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

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#272 Neuroinflammation: Why Your Brain Is "On Fire" & How to Put It Out | Dr. Jaquel Patterson

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