28 Days

Our medical rewrite today will be for 28 Days. The deep dive will be about medical management of alcohol use disorder. Movie suggestion form: https://tinyurl.com/8pa8svey References used in this episode Mechanisms of medications used for alcohol use disorder https://pubmed.ncbi.nlm.nih.gov/35133639/ LiverTox of disulfiram https://www.ncbi.nlm.nih.gov/books/NBK548103/ COMBINE study comparing naltrexone vs. acamprosate and medication management vs. cognitive behavior intervention https://pubmed.ncbi.nlm.nih.gov/16670409/ Meta-analysis of naltrexone and acamprosate for alcohol use disorder https://pubmed.ncbi.nlm.nih.gov/24825644/ Meta-analysis of long-acting naltrexone injection vs placebo https://pubmed.ncbi.nlm.nih.gov/34033183/ CYP2D6 Overview https://www.ncbi.nlm.nih.gov/books/NBK574601/ Hydrocodone pain control in CYP2D6 slow metabolizers https://pubmed.ncbi.nlm.nih.gov/34423496/ Systematic review of naltrexone efficacy in women with alcohol use disorder https://pubmed.ncbi.nlm.nih.gov/28247556/ Sex differences and opioid use https://pubmed.ncbi.nlm.nih.gov/24508560/ Review on sex/hormone differences and opioid effects https://pubmed.ncbi.nlm.nih.gov/34995646/ Acamprosate efficacy based on sex https://pubmed.ncbi.nlm.nih.gov/21895717/