EPISODE · Dec 2, 2025 · 18 MIN
286-靶向巨噬细胞的免疫细胞因子用于癌症免疫治疗
from 聊聊Sci
这篇文章重点介绍了一种新型的巨噬细胞靶向免疫细胞因子（immunocytokine），命名为 MiTEs。该研究旨在克服传统免疫细胞因子（ICKs）的全身毒性和治疗局限性，通过将抗TREM2抗体与经过工程改造的IL-2变体融合，并加入一个可被肿瘤微环境（TME）特异性蛋白酶 MMP14 剪切的阻断域，从而实现肿瘤特异性激活。实验数据，包括单细胞RNA测序（scRNA-seq）和体内模型结果，展示了 MiTEs 能够重塑肿瘤免疫微环境，有效激活和协同作用于骨髓细胞、T细胞和NK细胞，增强抗肿瘤免疫反应并显著降低全身副作用。研究人员认为 MiTEs 平台为开发下一代高效、安全的细胞因子疗法提供了新的方向。References: von Locquenghien M, Zwicky P, Xie K, et al. Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy[J]. Cell, 2025.前往小宇宙评论区与主播互动
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286-靶向巨噬细胞的免疫细胞因子用于癌症免疫治疗
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