29: Rethinking Agency: Predictors of Genetic Testing Intention among Latinos

Chavez-Yenter D et al., Genetics in Medicine - A cross-sectional SEM study of 503 English-fluent Latino adults applied the Integrated Behavioral Model to identify predictors of intention for carrier screening (CS) and cancer predisposition testing (CPT). Perceived agency emerged as the strongest predictor for both testing types, with family/friend norms supporting CS and attitudes showing negative associations. Key terms: Latino, carrier screening, cancer predisposition testing, integrated behavioral model, agency. Study Highlights:Using confirmatory factor analysis and structural equation models, the authors assessed attitudes, norms, and perceived agency as predictors of intention to use carrier screening and cancer predisposition testing among 503 English-speaking Latino adults. Perceived agency (self-efficacy and perceived control) was the most consistent predictor for both CS (β=.381, p<.01) and CPT (β=.559, p<.01). Norms from family and friends positively predicted CS intention (β=.350, p<.01) while attitudes were negatively associated with CS (β=-.313, p=.028) and marginally negatively associated with CPT (β=-.277, p=.053). Demographic and clinical covariates (age, gender, income, subethnicity, insurance) had smaller but significant associations with intention. Conclusion:To improve genetic testing uptake among Latino populations, interventions should prioritize strengthening perceived agency (navigation, referral, access) and leveraging family/friend normative influences rather than focusing solely on attitude/knowledge campaigns. QC:This episode was checked against the original article PDF and publication metadata.Scope: article metadata and core scientific claims from the narration, excluding analogies, intro/outro, and music.Factual QC score: 10/10.Metadata QC score: 10/10.Supported core claims: 4.Claims flagged for review: 0.Metadata checks passed: 4.Metadata issues found: 0.QC result: Pass. Music:Enjoy the music based on this article at the end of the episode. Article title:Rethinking Agency for Genetic Testing Intention among Latinos: Determining Predictors of Intention for Carrier Screening and Cancer Predisposition Testing First author:Chavez-Yenter D Journal:Genetics in Medicine DOI:https://doi.org/10.1016/j.gim.2025.101455 Reference:Chavez-Yenter D, Kaphingst KA. Rethinking Agency for Genetic Testing Intention among Latinos: Determining Predictors of Intention for Carrier Screening and Cancer Predisposition Testing. Genetics in Medicine (2025). doi: https://doi.org/10.1016/j.gim.2025.101455 License:© 2025 Published by Elsevier Inc. on behalf of American College of Medical Genetics and Genomics. Support:Base by Base – Stripe donations: https://donate.stripe.com/7sY4gz71B2sN3RWac5gEg00 Official website https://basebybase.com On PaperCast Base by Base you’ll discover the latest in genomics, functional genomics, structural genomics, and proteomics. Episode link: https://basebybase.com/episodes/rethinking-agency-genetic-testing-latinos