EPISODE · Sep 16, 2025 · 29 MIN
295. 神经元与小细胞肺癌的功能性突触
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本研究揭示了小细胞肺癌（SCLC）细胞与神经元之间存在功能性突触，挑战了此前认为中枢神经系统外癌症不形成此类连接的观点。研究团队通过小鼠模型中的插入诱变筛选和人类遗传及表达数据的重新分析，发现SCLC的基因信号与神经元和突触功能密切相关，证实了SCLC细胞具有类似肺神经内分泌细胞的表型，能够形成并接收神经递质介导的信号。这些突触连接能促进SCLC细胞的增殖，且至少部分依赖于神经元活动。此外，研究还探索了靶向谷氨酸信号通路作为治疗策略的潜力，发现谷氨酸释放抑制剂和谷氨酸受体激动剂在SCLC小鼠模型中单独或与化疗联用均显示出临床前活性，为开发SCLC新疗法提供了方向。内容来源：https://www.nature.com/articles/s41586-025-09434-9
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295. 神经元与小细胞肺癌的功能性突触
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