3 31 2025

Hi, This Week in Medicine, we will be discussing

 New England Journal of Medicine

Intensive Blood-Pressure Control in Patients with Type 2 Diabetes

Inebilizumab for Treatment of IgG4-Related Disease

Tezepelumab in Adults with Severe Chronic Rhinosinusitis with Nasal Polyps

Journal of  American Medical Association

Long-Term Risk of Stroke After Transient Ischemic Attack or Minor Stroke

A Systematic Review and Meta-Analysis

Annals of Internal Medicine

Excess Mortality Rate in Black Children Since 1950 in the United States: A 70-Year Population-Based Study of Racial Inequalities

British Medical Journal

Effects of intensive blood pressure treatment on orthostatic hypertension: individual level meta-analysis

Lancet

Mapping the global prevalence, incidence, and mortality of Plasmodium falciparum and Plasmodium vivax malaria, 2000–22: a spatial and temporal modelling study

journal of Hepatology

Predictors of hepatic flares after nucleos(t)ide analogue cessation – Results of a global cohort study (RETRACT-B study)

Intention-to-treat outcomes of patients with hepatocellular carcinoma receiving immunotherapy before liver transplant: The multicenter VITALITY study

Immune checkpoint inhibitors exhibit significant potential in neoadjuvant therapy  Gastroenterology

Multi-Cohort Analysis Reveals Altered Archaea in Colorectal Cancer Fecal Samples Across Populations

Clinical Gastroenterology

Treatment of the Buried Bumper Syndrome​​​​​: A Retrospective Multicenter Study With Inclusion of 160 Cases

Clinical Infectious Diseases

Peer-Assisted Telemedicine for Hepatitis C in People Who Use Drugs: A Randomized Controlled Trial

Rheumatology 

The Design of a Randomized Controlled Active Comparator Strategy Trial for Gout: Treat to Target Serum Urate Versus Treat to Avoid Symptoms

 Circulation

Activation of Imprinted Gene PW1 Promotes Cardiac Fibrosis After Ischemic Injury

=  Journals of the American College of Cardiology

Transcatheter vs Surgical Aortic Valve Replacement in Lower-Risk Patients: An Updated Meta-Analysis of Randomized Controlled Trials

 JAMA Cardiology

Intravascular Sympathetic Stimulation to Facilitate Catheter Ablation of Premature Ventricular Complexes

  Journal of Clinical Endocrinology & Metabolism

Iron Status Correlates Strongly to Insulin Resistance Among US Adults: A Nationwide Population-Based Study

Diabetes care

Three-Year Follow-up After Antiviral Treatment in New-Onset Type 1 Diabetes: Results From the Diabetes Virus Detection and Intervention Trial 

Neurology

Associations of Plasma Neurofilament Light Levels With Brain Microstructure and Macrostructure and Cognition in the Community-Based Rhineland Study

Chest

Implementation and Effectiveness of Guideline-Recommended Clinical Activities for Children With Asthma

 The American Journal of Respiratory and Critical Care Medicine

Randomized Clinical Trial of the Four Supports Intervention for Surrogate Decision-Makers in Intensive Care Units

 Clinical Journal of American Society of Nephrology

A Pilot Trial of Nicotinamide Riboside and Coenzyme Q10 on Inflammation and Oxidative Stress in CKD

 Kidney International reports

Efficacy and Safety of Rituximab in Antiglomerular Basement Membrane Disease

Obinutuzumab and Ofatumumab are More Effective Than Rituximab in the Treatment of Membranous Nephropathy Patients With Anti-Rituximab Antibodies