EPISODE · Dec 8, 2025 · 17 MIN
304-感觉神经元通过伪突触驱动胰腺癌
from 聊聊Sci
这篇研究论文考察了感觉神经元如何与脑外部的胰腺导管腺癌 (PDAC) 细胞相互作用。研究人员报告发现，感觉神经末梢与癌细胞之间建立了特殊的连接结构，称为假突触。在这些部位，癌细胞选择性富集了N-甲基-D-天冬氨酸受体亚基 GRIN2D，使其能够响应神经元释放的谷氨酸。这种谷氨酸驱动的信号传导促进了肿瘤生长和扩散，并通过涉及 TGFA-EGFR 的信号轴进一步增强了神经浸润，形成正反馈循环。通过透射电镜和扫描电镜分析，研究证实了人体 PDAC 样本中存在这些物理性的假突触结构。至关重要的是，在小鼠模型中，干扰这一谷氨酸-GRIN2D信号通路能够显著提高生存率，为癌症神经科学指导的肿瘤疗法提供了新的靶点。References: Ren L, Liu C, Çifcibaşı K, et al. Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses[J]. Cancer cell, 2025.前往小宇宙评论区与主播互动
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304-感觉神经元通过伪突触驱动胰腺癌
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