#31 | GMJ Podcast | Daily Multivitamins and Biological Ageing — COSMOS Trial

In this episode of the GMJ Podcast — the official podcast of the Georgian Medical Journal, we examine recent scientific evidence exploring whether daily multivitamin supplementation may influence biological ageing.The discussion is based on findings published in Nature Medicine from the COSMOS randomized clinical trial. Researchers analysed the effects of multivitamin–multimineral supplementation and cocoa extract on epigenetic ageing markers among older adults.Epigenetic clocks, which estimate biological age using DNA methylation patterns, were used to evaluate potential biological ageing processes. The results indicated that participants who received daily multivitamin supplementation demonstrated a modest but statistically significant slowing of several second-generation epigenetic ageing markers during the two-year intervention period.In contrast, cocoa extract supplementation did not show measurable effects on the analysed epigenetic ageing indicators.Although the observed effect was relatively small, the findings contribute to the growing scientific discussion on whether nutritional interventions may influence biological ageing and long-term health outcomes.ReferenceLi S et al. Effects of daily multivitamin–multimineral and cocoa extract supplementation on epigenetic aging clocks in the COSMOS randomized clinical trial. Nature Medicine. 2026. doi:10.1038/s41591-026-04239-3