310: Infant gut microbiota restoration — maternal FMT, Bifidobacterium and Bacteroides recovery after C‑section

Korpela K et al., Gut Microbes - Review finds maternal fecal microbiota transplantation and targeted probiotics can restore Bifidobacterium and Bacteroides after C‑section or intrapartum antibiotics, with breastfeeding aiding recovery. Key terms: maternal fecal microbiota transplantation, C-section, Bifidobacterium, vaginal seeding, probiotics. Study Highlights:This review focuses on term infants, particularly C‑section and intrapartum antibiotic–exposed neonates, synthesizing cohort and intervention data using 16S rRNA gene amplicon sequencing and metagenomic approaches. Maternal fecal microbiota transplantation (maternal FMT) shifted C‑section infants’ gut communities to resemble vaginally born infants and uniquely restored Bacteroidaceae, while a Bifidobacterium–Lactobacillus–FOS supplement increased bifidobacteria; vaginal seeding did not normalize overall gut composition. The authors link restoration of key taxa to potential reductions in risks such as allergy and overweight and emphasize breastfeeding as an essential adjunct to restoration strategies. Conclusion:Evidence supports action to address early-life gut microbiota disruption: probiotics and maternal FMT show promising restorative effects, but optimal, scalable solutions and long-term immune outcomes remain to be established. Music:Enjoy the music based on this article at the end of the episode. Article title:Infant gut microbiota restoration: state of the art First author:Korpela K Journal:Gut Microbes DOI:10.1080/19490976.2022.2118811 Reference:Korpela K, de Vos WM. Infant gut microbiota restoration: state of the art. Gut Microbes. 2022;14(1):e2118811. https://doi.org/10.1080/19490976.2022.2118811 License:This episode is based on an open-access article published under the Creative Commons Attribution 4.0 International License (CC BY 4.0) - https://creativecommons.org/licenses/by/4.0/ Support:Base by Base – Stripe donations: https://donate.stripe.com/7sY4gz71B2sN3RWac5gEg00 Official website https://basebybase.com On PaperCast Base by Base you’ll discover the latest in genomics, functional genomics, structural genomics, and proteomics. Episode link: https://basebybase.com/episodes/maternal-fmt-bifidobacterium-restoration QC:This episode was checked against the original article PDF and publication metadata for the episode release published on 2026-03-07. QC Scope:- article metadata and core scientific claims from the narration- excludes analogies, intro/outro, and music- transcript coverage: Audited the transcript sections describing vertical transmission, HMOs and breast milk, birth-mode and antibiotic effects, restoration interventions (vaginal seeding, Lactobacillus probiotics, Bifidobacterium-Lactobacillus-FOS multispecies, maternal FMT), PCA-based analysis, preterm considerations, and long-term health- transcript topics: Vertical transmission and HMOs feeding infant gut microbes; Birth mode and intrapartum antibiotic effects on microbiota; Microbiota restoration interventions: vaginal seeding, probiotics, multispecies probiotics, maternal FMT; PCA analysis as a measure of restoration efficacy; Bifidobacteriaceae and Bacteroidaceae dynamics across interventions; Preterm infant microbiota and NICU interventions QC Summary:- factual score: 10/10- metadata score: 10/10- supported core claims: 7- claims flagged for review: 0- metadata checks passed: 4- metadata issues found: 0 Metadata Audited:- article_doi- article_title- article_journal- license Factual Items Audited:- Maternal FMT can restore CS-born infant gut microbiota toward vaginal births, with persistence at 1 and 3 months- Bacteroidaceae restoration is achieved by maternal FMT; other interventions fail to...