#311 - Dr. F. Perry Wilson on HOW MEDICINE WORKS AND WHEN IT DOESN'T

Yale School of Medicine physician and researcher F. Perry Wilson, MD, MSCE, chats with Trey Elling about HOW MEDICINE WORKS AND WHEN IT DOESN’T: LEARNING WHO TO TRUST TO GET AND STAY HEALTHY. Topics include: Goal with the book (0:00) Pharma’s role with patient mistrust (1:57) Pharma’s influence on doctors (6:49) Generic drugs not such an easy fix (10:22) How medical errors commonly lead to death (12:34) Surrogate outcomes (15:50) Getting patients to change their minds for GOOD reasons (17:44) Combatting motivated reasoning (20:44) The “biggest secret in medicine” (26:22) Factoring in side effects when considering a drug (29:32) Doctors’ responsibility to help patients with despair (31:28) Randomized controlled trials, aka RCTs (37:48) How RCTs go wrong (44:19) The difficulty with replication (47:29) Why “open data” isn’t already the standard with RCTs (50:35) The problem with the “middle man” in patient care (53:39) An alternative to the current US healthcare system (57:06) How patients can move closer to doctors by embracing uncertainty (1:00:15)