#317 - 📑 Journal Club - The Complete Episode from June 8th 2025

In this week’s Journal Club, Ben and Daphna dive into the latest report from the American Academy of Pediatrics on the management of patent ductus arteriosus (PDA) in preterm infants. They dissect the nuances of prophylactic versus selective treatment, review recent meta-analyses, and explore why early intervention might not yield better outcomes despite effective PDA closure. They also break down new echocardiographic criteria for diagnosing a hemodynamically significant PDA and discuss the role of transcatheter procedures.The conversation then shifts to MRI timing and classification in neonatal encephalopathy, highlighting recent Canadian consensus recommendations for standardizing imaging protocols post-therapeutic hypothermia. The episode wraps up with a look at the TOHOP trial on permissive hypotension, challenging long-standing blood pressure treatment thresholds in preterm infants.Listeners will gain a pragmatic view of evolving clinical practices and research gaps in neonatal care, particularly for infants with PDA and hypoxic-ischemic encephalopathy. If you’re looking to stay current on evidence-based recommendations without the fluff, this episode is for you. Support the showAs always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!