EPISODE · Dec 25, 2025 · 17 MIN
337-TDP-43神经退行中杆状小胶质细胞的神经保护作用
from 聊聊Sci
该研究利用 TDP-43 神经变性的小鼠模型 (rNLS8) ，探讨了早期皮层神经元过度兴奋与小胶质细胞反应之间的关系。研究人员通过体内电生理记录和钙成像发现，神经元过度兴奋诱导了形态独特的棒状小胶质细胞的形成。进一步的单细胞和空间 RNA 测序显示，这种小胶质细胞亚群具有独特的转录特征，与神经元树突紧密接触并可能通过突触重塑发挥神经保护作用。此外，研究还表明 TREM2/DAP12 信号通路对棒状小胶质细胞的形成至关重要，TREM2 缺乏会加剧神经元过度兴奋和疾病症状。 References: Xie M, Liang Y, Miller A S, et al. Rod-shaped microglia interact with neuronal dendrites to attenuate cortical excitability during TDP-43-related neurodegeneration[J]. Immunity, 2025. 前往小宇宙评论区与主播互动
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337-TDP-43神经退行中杆状小胶质细胞的神经保护作用
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